Woman taking medication.Photo: getty
Patients and doctors are in shock afterearly trials of a drug to treat rectal cancerled to remission in every participant.
The trial was small,with just 12 patients, but after taking the drug dostarlimab for six months there was no identifiable cancer in any of the participants, with all of their scans coming back completely clear.
“I believe this is the first time this has happened in the history of cancer,” Dr. Luis A. Diaz Jr. of Memorial Sloan Kettering Cancer Center, one of the study authors,toldThe New York Times.
“What’s really remarkable is this is the first time I know of in solid tumor oncology where we’ve had a 100% complete response, and we’ve completely omitted the normal standard of care,” he addedto Stat News.
The patients had expected to go through the usual, difficult treatments for rectal cancer, which include chemotherapy, radiation and surgery and often leave them needing colostomy bags and with permanent complications like bowel, urinary and erectile dysfunction. But the experimental trial worked better than anyone imagined.
None of the 12 patients need further treatment.
“There were a lot of happy tears,” Dr. Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center and a co-author of the study,published Sunday in theNew England Journal of Medicine, told theTimes.
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Other cancer researchers who have reviewed the results told theTimesthat the drug looks promising, but alarger-scale trial is neededto see if it will work for more patients and if the cancers are truly in remission.
For one patient in the trial, Sascha Roth, she has been in the clear for two years now. Cercek was the one to tell her that “there is absolutely no cancer.”
“I told my family,” Roth told theTimes. “They didn’t believe me.”
“It’s incredibly rewarding,” Cerceksaid in a press releasefrom the hospital, “to get these happy tears and happy emails from the patients in this study who finish treatment and realize, ‘Oh my God, I get to keep all my normal body functions that I feared I might lose to radiation or surgery.’ "
source: people.com
