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A unexampled drug can give human pelt a " natural " tangent — it activates the same process that causes hide to darken in the Sunday , without pic to harmfulultraviolet ( UV ) rays , according to former research .
In the discipline , research worker apply this drug to human skin samples in a lab cup of tea and line up that it darkened the tegument , because it spurred production of thepigment melanin . And the drug does n’t damage DNA as the sunlight ’s UV shaft do .
Much more research is postulate to determine if the drug is safe before it could be used in citizenry , the investigator said . But they are promising that the drug might actually protect mass againstskin Crab , because the presence of melanin in the pelt is connect with a gloomy peril of skin cancer . [ 7 Common Summer Health Concerns ]
" It ’s possible [ the drug ] may direct to novel ways of protect against UV - induced skin damage and genus Cancer formation , " Dr. David Fisher , a co - author of the new research and the tribal chief of dermatology at Massachusetts General Hospital , said in a affirmation .
The new study builds upon the investigator ' former work , which investigated the molecular signals involved in the body ’s rude tanning reply . In a 2006 study , the researcher worked with " red - haired mice , " which ca n’t produce Robert Brown - colored melanin . These mice , likehuman redheads , have a genetic magnetic variation that prevents cells from setting off a cascade of sign that would eventually lead to brown melanin product .
In that 2006 study , the researcher found that a compound called forskolin could actuate the production of melanin in these mouse , because forskolin " shunt " the genetic dislocation and activates a protein further along in the pathway that produce melanin , the researcher said .
But that study also found that forskolin did n’t set off the yield of melanin in man , likely because human cutis is much thick than sneak skin , and the compound could not permeate human hide .
In the raw study , the researcher used drugs call SIK inhibitors , which affect a protein further along in the melanin output nerve pathway . The SIK inhibitor drug darken the skin of red - haired mice , and after the treatment was stopped , the tan gradually pass off , just as a " material " tan would . When the researcher applied the drugs to human skin sample for eight days , they regain that the drug did pervade the hide , and led to the production of melanin and subsequent skin darken .
Still , there is reason to be conservative about the safety of SIK inhibitors in humans . SIK inhibitor work by turn on a gene address MITF , and mutations in this cistron can cause cancer in certain cases , the researchers order . The SIK inhibitor drugs used in the study would n’t be expected to do mutations in the MITF factor , but further studies are needed to better understand the activity of these drugs , they said .
Thestudyis put out in the June takings of the journal Cell Reports . The researchers ' institutions — Massachusetts General Hospital and the Dana - Farber Cancer Institute — have lodge a patent covering the finding of the study .
Original article onLive Science .
