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The eyes , long described as the windows to the soul , seem to be window to the brain , as well : scientist have develop an eye - scan technique that may observe Alzheimer ’s disease at its earliest stagecoach , before major symptom seem .
With early detecting , a person could seektreatment for Alzheimer’sat a time when therapies would be most effective at slow down the progress of the memory board - pluck disease , the research worker enunciate .
The enquiry was present today ( May 5 ) at the annual coming together of the Association for Research in Vision and Ophthalmology ( ARVO ) in Seattle .
Alzheimer ’s disease , the most vulgar configuration of dementia , is an epidemic that shows no signs of slack , consort to the Centers for Disease Control and Prevention . Death rates for Alzheimer ’s diseaseare increasing : More than 5 million Americans exist with the disease , and by 2050 , this telephone number is projected to go up to 14 million , according to CDC statistics .
There is no remedy for Alzheimer ’s , but medicament can slow up the ontogenesis of many of the Hellenic symptoms , such as loss of retentivity and communication acquisition , modality swings and slump . [ 7 slipway the Mind and trunk Change With years ]
The movement of Alzheimer ’s is strange . The disease appear to be associated with the accumulation of misfolded proteins in the wit calledbeta - amyloid and tau . The misfolded proteins can constitute tangle in the neural internet of the brain , break up normal communicating between neurons .
Doctors can only be sure that a affected role had Alzheimer ’s after he or she dies , because an autopsy is needed to provide definitive proof of the presence of these microscopic brain tangles . preferred scans of the brainsof be multitude can provide doctors with grounds that amyloid and tau are accumulating , but these scans are expensive and invasive , requiring the patient to be interject with radioactive tracers that hold with these proteins and glow during the scan .
In the new report , investigator in New England devised a unlike , noninvasive approach to finding Alzheimer ’s other , using optical coherence tomography ( OCT ) , an demonstrate aesculapian imaging proficiency used to observe microscopic detail . The OCT machine can be configured to painlessly scana patient ’s retina , the tissue paper in the back of the oculus , to see for abnormalities .
The investigator recruited 63 subject participant who were at high risk for Alzheimer ’s disease , based on emerging symptom and family chronicle . The investigator first conducted PET scans to found the extent of the participants ' genus Beta - amyloid accumulation . Then , they perform OCT scan and compared the results . [ 6 Foods That Are Good For Your mental capacity ]
The researchers used a technique called profane laser autofluorescence in conjunction with the OCT , which verify cellular components to glow without requiring the injectant of any dye or chemical substance tracer .
The OCT scan could not straight observe beta - amyloid protein , but it did reveal shadow - like inclusion bodies — totality of cellular material , likely proteins — that correlate well with the level of genus Beta - amyloid close to the retina let on by the PET scan , according to Cláudia Santos , a graduate educatee at the University of Rhode Island who led the study .
" There is no discourse for Alzheimer ’s , [ but ] it may be because we are trying to intervene too late in the disease [ cognitive operation ] and ca n’t reverse the dementedness , " Santos told Live Science . This OCT technique " might be a good screening tool forpreclinical Alzheimer ’s , since the OCT can be performed at any ophthalmologist clinic . "
Santos said the OCT technique , once perfect , could be a first dance step in evaluate the maturation of Alzheimer ’s disease . Should the OCT scan disclose evidence of genus Beta - amyloid , doctors could then execute PET scans for a more thoroughgoing diagnosing and then order medicine .
" Our subject field is longitudinal [ conducted over time ] , so we will execute the OCT and PET scan again in about 20 months after these baseline result … to see [ if ] the spirit level of amyloid - genus Beta is increasing , " Santos said . " We hope this study can be replicated with different subjects . "
The research was conducted at Lifespan - Rhode Island Hospital in Providence and was co - led by Peter Snyder , a prof of neurology at Brown University , also in Providence .
