Double Your Lifespan with a Drug that Mutates Your Ribosomes

It ’s been hump for a while that restricting your diet will increase your lifespan , but now researcher have demo one reason why : Eating less induce your ribosomes ( your cells ’ protein factory ) to mutate . And it ’s looking like mutate ribosomes ( envision here ) could be one key to life propagation . The salutary intelligence is that you may not have to starve yourself to mutate your ribosomes anymore . Biologists at the University of Washington have handle to get the life - extending mutation in ribosomes with a drug that doubles the life of yeast cellular phone .

The key is to turn down protein - product in mobile phone , which is why eating less can cause lifespan filename extension . harmonize to the University of Washington :

In this project , the UW researcher studied many dissimilar line of barm cadre that had lower protein production . They found that mutations to the ribosome , the cell ’s protein factory , sometimes led to increased life duad . Ribosomes are made up of two parts — the prominent and small subunit — and the researchers judge to sequester the animation - span - related mutation to one of those division .

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“ What we find right away was that the long - subsist stock always had mutations in the big ribosomal subunit and never in the small subunit , ” read the study ’s lead author , Kristan Steffen , a graduate student in the UW Department of Biochemistry .

The research worker also tested a drug called diazaborine , which specifically interferes with synthesis of the ribosomes ’ large subunits , but not small subunits , and found that treating cells with the drug made them hold up about 50 percentage longer than untreated cells . Using a series of genetic tests , the scientist then demonstrate that depletion of the ribosomes ’ with child subunits was likely to be increasing life span by a mechanism related to dietary restriction — the TOR bespeak pathway .

The study will be published tomorrow in the journal Cell . Image viaNSF .

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